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Lawrence H. Block, Ph.D.
Professor of Pharmaceutics
Director of the Center for Biotechnology
437 Mellon Hall
T 412.396.6362
E block@duq.edu
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| Educational Background |
Ph.D --University of Maryland
M.S. --University of Maryland
B.S. (Pharmacy)--University of Maryland
Lawrence H. Block
is Professor of Pharmaceutics at the Mylan School
of Pharmacy and Graduate School of Pharmaceutical
Sciences and Director of the Center for Biotechnology
at Duquesne University. Dr. Block was educated
at the University of Maryland where he earned
his B.S. in Pharmacy, M.S., and Ph.D. degrees.
Dr. Block is a member
of the American Pharmaceutical Association Academy
for Pharmaceutical Research and Science (APhA-APRS),
American Association of Pharmaceutical Scientists
(AAPS), American Society for Testing Materials
(ASTM), Controlled Release Society, International
Society for Pharmaceutical Engineering, and the
New York Academy of Sciences.
Dr. Block is a Past Chair
of both the Teachers of Pharmaceutics Section
of the American Association of Colleges of Pharmacy
and the Basic Pharmaceutical Sciences Section
of the APhA-APRS. He currently serves as a member
of the United States Pharmacopeia's Council of
Experts. A recipient in 2000 of the Duquesne University
President's Award for Excellence in Scholarship
and a Fellow of the APhA-APRS, Dr. Block has authored
more than 80 publications and mentored more than
60 Pharm.D., M.S., and Ph.D. research students
in the course of his professional career. His
research interests embrace pharmacokinetics, pharmacodynamics,
drug and cosmetic delivery system technology,
and pharmaceutical engineering. He has served
as a Visiting Scholar at Kobe Gakuin University
in Kobe, Japan and Visiting Professor of Pharmaceutical
Sciences at the Center for Pharmacogenetics at
the University of Pittsburgh School of Pharmacy.
Courses Taught
Graduate Courses:
- GPHSC 504 - Regulatory Aspects of Industrial Practice
- 2 cr.
- GPHSC 505, 506 - Cosmetic Science and Technology
- 2 cr., lecture, 1 cr., lab
- GPHSC 507 - Data Analysis and Modeling - 2 cr.
- GPHSC 510 - Advanced Pharmacokinetics I - 2 cr.
- GPHSC 615 - Advanced Pharmaceutics I - 3 cr.
- GPHSC 616 - Advanced Pharmaceutics II - 3 cr.
Professional Courses:
- PHCEU 430 - Biopharmaceutics - 3 cr.
- PHCEU 430L - Pharmaceutical Analysis/Biopharmaceutics
Lab. - 1 cr.
- PHPRC 460 - Issues in Women's Health - 3 cr. [2
hr lecture on gender-related differences in biopharmaceutics
and pharmacokinetics]
- PHINT 490 - Integrated Case Studies - 0.5 cr.
[1 semester]
Current Research Foci
- Pharmaceutic aspects of chitin, chitosan, and chitinosans
Scale-up of non-parenteral liquids and semi-solids
Hydrophilic gels as drug delivery systems
Select Patents
- L. H. Block and S. S. Sabnis, "Methods of Creating
a Unique Chitosan and Employing the Same to Form
Complexes with Drugs, Delivery of the Same within
a Patient and a Related Dosage Form," U.S. Patent
5,900,408 (May 4, 1999).
- L. H. Block and S. S. Sabnis, "Methods of Creating
a Unique Chitosan and Employing the Same to Form
Complexes with Drugs, Delivery of the Same within
a Patient and a Related Dosage Form," U.S. Patent
5,830,883 (November 3, 1998).
Select Papers
- A. Hashash, D. L. Kirkpatrick, J. S. Lazo, and L.
H. Block, "Solubility, ionization, and partitioning
behavior of unsymmetrical disulfide compounds: Alkyl
2-imidazolyl disulfides," J. Pharm. Sci. 91: 1686-1692
(2002)
- A. Hashash, D. L. Kirkpatrick,
M. J. Egorin, L. H. Block, and J. S. Lazo, "Reversed-
and norma-phase high-performance liquid chromatographic
methods for the determination of the novel anti-tumor
agent: 1-methylpropyl-2-imidazolyl disulfide," J.
Chromaatog. B. 768: 239-246 (2002)
- S. Ramanathan and L. H.
Block, "The use of chitosan gels as matrices for
electrically-modulated drug delivery," J. Contr.
Rel. 70: 109-123 (2001).
- L. H. Block, "Process scale-up for pharmaceutical
liquids and semisolids," Am. Pharm. Rev. 3 (4):
12, 14-15 (2000).
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H. Tokumitsu, H. Ichikawa, T. K. Saha, Y. Fukumori,
and L. H. Block, "Design and preparation of gadolinium-loaded
chitosan particles for cancer neutron capture therapy,"
- S. Sabnis and L. H. Block,
"Chitosan as an Enabling Excipient for Drug Delivery
Systems. I. Molecular Modifications," Int. J. Biol.
Macromol. 27: 181-186 (2000).
- K. Hojo, M. Maeda, Y. Mu, H. Kamada, Y. Tsutsumi,
Y. Nishiyama, T. Yoshikawa, K. Kurita, L. H. Block,
T. Mayumi, and K. Kawasaki, "Facile Synthesis of
a Chitosan Hybrid of a Laminin-related Peptide and
Its Antimetastatic Effect in Mice," J. Pharm. Pharmacol.
52: 67-73 (2000).
- B. Li, S. Li, Y. Tan, D.
B. Stolz, S. C. Watkins, L. H. Block, and L. Huang,
"Lyophilization of Cationic Lipid-Protamine-DNA
(LPD) Complexes," J. Pharm. Sci. 89: 355-364 (2000).
P. R. Rege and L. H. Block, "Chitinosan Processing:
Influence of Process Parameters During Acidic and
Alkaline Hydrolysis and Effect of the Processing
Sequence on the Resultant Chitinosan's Properties."
Carbohydrate Research 321: 235-245 (1999).
- K. Hojo, M. Maeda, Y. Mu,
H. Kamada, Y. Tsutsumi, Y. Nishiyama, T. Yoshikawa,
K. Kurita, L. H. Block, T. Mayumi, and K. Kawasaki,
"Preparation of a Chitosan Hybrid of an Antimetastatic
Laminin-related Peptide," Pharm. Pharmacol. Commun.
5: 277-280 (1999).
- P. R. Rege, D. J. Shukla, and
L. H. Block, "Chitinosans as tableting excipients
for modified release delivery systems" Int. J. Pharm.
181: 49-60 (1999).
- H. Tokumitsu, H. Ichikawa,
Y. Fukumori, and L. H. Block, "Preparation of Gadopentetic
Acid-Loaded Chitosan Microparticles for Gadolinium
Neutron-Capture Therapy of Cancer by a Novel Emulsion-Droplet
Coalescence Technique," Chem. Pharm. Bull. 47: 838-842
(1999).
- Y. Fukumori, H. Tamura,
K. Jono, M. Miyamoto, H. Tokumitsu, H. Ichikawa,
and L. H. Block, "Dry grinding of chitosan powder
by a planetary ball mill" Adv. Powder Technol. 9
(4): 281-292 (1998).
- S. Sabnis, P. Rege, and L. H. Block, Use of Chitosan
in Compressed Tablets of Diclofenac Sodium: Inhibition
of Drug Release in an Acidic Environment," Pharm.
Develop. Technol. 2: 243-255 (1997).
- S. Sabnis and L. H. Block, "Improved Infrared Spectroscopic
Method of Analysis of Degree of N-Deacetylation
of Chitosan," Polymer Bull. 39: 67-71 (1997).
Select Monographs
- L. H. Block, "Non Parenteral Liquids & Semisolids,"
Chapter 3, in M. Levin, ed., Process Scale-Up in
the Pharmaceutical Industry, Marcel Dekker, New
York, 2001, pp. 57-94.
- L. H. Block and A.B.C.
Yu, "Pharmaceutical Principles and Drug Dosage Forms,"
Chapter 3 in Comprehensive Pharmacy Review, 4th
ed., L. Shargel, A.H. Mutnick, P.F. Souney, L.N.
Swanson, eds., Lippincott Williams & Wilkins, Baltimore,
2001, pp. 28-77.
- L. H. Block and C.C. Collins,
"Biopharmaceutics and Drug Delivery Systems," Chapter
4 in Comprehensive Pharmacy Review, 4th ed., L.
Shargel, A.H. Mutnick, P.F. Souney, L.N. Swanson,
eds., Lippincott Williams & Wilkins, Baltimore,
2001, pp. 78-91.
- L. H. Block, "Medicated
Topicals," Chapter 44 in Remington: The Science
and Practice of Pharmacy, 20th ed., Lippincott Williams
& Wilkins, Baltimore & Philadelphia, 2000, pp. 836-857.
- L. H. Block, "Scale-Up
of Disperse Systems: Theoretical and Practical Aspects,"
in Pharamceutical Dosage Forms: Disperse Systems,
2nd ed., Chapter 9 in vol. 3, H.A. Lieberman, M.
M. Rieger and G. S. Banker, eds., Marcel Dekker,
Inc., New York, 1998, pp. 363-394.
Select Presentations
-
AAPS, Indianapolis, IN, October 2000 [abstract:
AAPS PharmSci. 2 (4), Suppl., 2000]: "Conductometric
Evaluation of Chitosan-Carrageenan Complexes in
- AAPS, Indianapolis, IN,
October 2000 [abstract: AAPS PharmSci. 2 (4), Suppl.,
2000]: "Controlled Drug Delivery from Tablets Using
a Chitosan-Carrageenan Matrix"
- AAPS, Indianapolis, IN,
October 2000 [abstract: AAPS PharmSci. 2 (4), Suppl.,
2000]: "Molecular Weight Characterization of Chitosans
and Carrageenans Using SEC with Triple Detector"
- AAPS, Indianapolis, IN,
October 2000 [abstract: AAPS PharmSci. 2 (4), Suppl.,
2000]: "Preparation of Chitosan Microparticles by
a Planetary Mill for Their Possible Applications
as Drug Carriers"
- AAPS, New Orleans, LA, November 1999 [abstract:
AAPS PharmSci. 1 (4), Suppl., 1999]: "Spray Dried
Chitosans as Excipients for Use in Drug Delivery
Systems"
- AAPS, New Orleans, LA,
November 1999 [abstract: AAPS PharmSci. 1 (4), Suppl.,
1999]: "Micromeritic Characterization of Chitosans"
- AAPS, New Orleans, LA,
November 1999 [abstract: AAPS PharmSci.1 (4), Suppl.,
1999]: "Determination of the Degree of N-Deacetylation
of Chitosan following Batch or Continuous Processing:
Development of an Improved Infrared Method"
- AAPS, San Francisco, CA , November 1998 [abstract:
PharmSci. 1 (1), 1998]: "Use of Electrolytes in
Directly Compressed Naproxen Sodium-Chitosan Tablets:
Controlled In Vitro Release Under Simulated Gastrointestinal
Conditions"
- AAPS, San Francisco, CA
, November 1998 [abstract: PharmSci. 1 (1), 1998]:
"Chitosan Processing: Study of the Kinetics of Chitosan
Depolymerization in Acidic Solution"
- AAPS, San Francisco,
CA , November 1998 [abstract: PharmSci. 1 (1), 1998]:
"A Simple, Sensitive GC/MS Method for the Quantitation
of d-alpha-Tocopherol Quinone"
- Controlled Release Society,
25th International Symposium on Controlled Release
of Bioactive Materials, Las Vegas, Nevada, June,
1998: "Chitinosans as Tableting Excipients for Modified
Release Delivery Systems"
- AAPS, Boston, MA, November
1997: "Effect of the Deacetylation-Depolymerization
Sequence on the Manufacture of Chitosans"
- AAPS, Boston, MA, November 1997: "The Use of Cationic
Hydrogels as Matrices for Electrically Modulated
Drug Delivery. II"
- Controlled Release Society,
25th International Symposium on Controlled Release
of Bioactive Materials, Las Vegas, NV, June, 1998:
"Electrically-induced syneresis in anionic gel systems
and its contribution to anionic drug delivery"
- American Association of
Pharmaceutical Scientists, Boston, MA, November
1997 [abstract: Pharm. Res. 14: S-387 (1997)]: "Effect
of the Deacetylation-Depolymerization Sequence on
the Manufacture of Chitosans"
- American Association of
Pharmaceutical Scientists, Boston, MA, November
1997 [abstract: Pharm. Res. 14: S-310 (1997)]: "The
Use of Cationic Hydrogels as Matrices for Electrically
- Controlled Release Society,
24th International Symposium on Controlled Release
of Bioactive Materials, Stockholm, Sweden, June
1997: "The Use of Cationic Hydrogels as Matrices
for Electrically Modulated Drug Delivery"
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