Patrick Flaherty, Ph.D.
Assistant Professor of Medicinal Chemistry

445 Mellon Hall
T 412.396.1847
E flahertyp@duq.edu

Ph.D. MEDICINAL CHEMISTRY
Advisor: Professor Joseph G. Cannon, University of Iowa
B.S.- CHEMISTRY University of Pittsburgh.

• Progress Toward CDK-5/P25 Inhibitors based on Roscovitine, Jain, P.; P. Flaherty Duquesne University Graduate research Symposium, March 2007.
• Design and Synthesis of  p25/CDK5 inhibitors based on Roscovitine. Bleasdell, G., P. Flaherty, and P. Jain.  Duquesne University Undergraduate Research Experience Symposium. 2006. Pittsburgh.

• Progress Toward CDK-5/P25 Inhibitors based on Roscovitine, Jain, P.; P. Flaherty Duquesne University Graduate research Symposium, March 2007.
• Preparation of diaminoalkanes, particularly N-(1-aminopropan-2-yl)piperidine-1-carboxamides, as aspartic protease inhibitors.  Baldwin, J.J., et al.  2006, (Vitae Pharmaceutical, Inc, USA). Application: WO2005-US36230, 2006042150. p. 755 pp.
• Design and Synthesis of  p25/CDK5 inhibitors based on Roscovitine. Bleasdell, G., P. Flaherty, and P. Jain.  Duquesne University Undergraduate Research Experience Symposium. 2006. Pittsburgh.
• Synthesis and Anti-Tubulin Activity of a 3'-(4-Azidophenyl)-3'-dephenylpaclitaxel Photoaffinity Probe.     Spletstoser, Jared T.; Flaherty, Patrick T.; Himes, Richard H.; Georg, Gunda I.    Department of Medicinal Chemistry,  University of Kansas,  Lawrence,  KS,  USA.    Journal of Medicinal Chemistry  (2004),  47(26),  6459-6465. 
• Formal Total Synthesis of (+)-Salicylihalamides A and B: A Combined Chiral Pool and RCM Strategy.     Yang, KyoungLang; Blackman, Burchelle; Diederich, Wibke; Flaherty, Patrick T.; Mossman, Craig J.; Roy, Subho; Ahn, Yu Mi; Georg, Gunda I.    Department of Medicinal Chemistry, Center for Cancer Experimental Therapeutics and the Drug Discovery Program, Higuchi Biosciences Center,  University of Kansas,  Lawrence,  KS,  USA.    Journal of Organic Chemistry  (2003),  68(26),  10030-10039. 
• Formal synthesis of the (+)-salicylihalamides.     Yang, Kyoung Lang; Ahn, Yu Mi; Blackman, Burchelle; Diederich, Wibke E.; Flaherty, Patrick T.; Mossman, Craig J.; Roy, Subho; Georg, Gunda I.    Department of Medicinal Chemistry,  University of Kansas,  Lawrence,  KS,  USA.    Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22, 2002  (2002),     ORGN-798.
• Synthesis of (-)-Salicylihalamides A and B based on a chiral-pool approach.     Blackman, Burchelle; Diederich, Wibke E.; Flaherty, Patrick T.; Georg, Gunda I.; Haack, Torsten; Mossman, Craig J.; Roy, Subho; Srinivas, Pusuluri; Yang, KyoungLang.    Department of Medicinal Chemistry,  University of Kansas,  Lawrence,  KS,  USA.    Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22, 2002  (2002),     ORGN-788
• Total synthesis of Tyloindicine H.     Dutta, Dinah; Flaherty, Patrick T.; Georg, Gunda I.; Himes, Richard H.; Liu, Yanbin; Telikepalli, Hanumaiah; Tunoori, Ashok Rao; Victory, Sam F.    Department of Medicinal Chemistry,  University of Kansas,  Lawrence,  KS,  USA.    Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22, 2002  (2002),     ORGN-634.
• Design, synthesis and biological evaluation of novel paclitaxel photoaffinity labels.     Spletstoser, Jared T.; Flaherty, Patrick T.; Georg, Gunda I.; Himes, Richard H.    Department of Medicinal Chemistry,  University of Kansas,  Lawrence,  KS,  USA.    Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22, 2002  (2002),     MEDI-134.
• Synthesis of the salicylihalamides.     Yang, KyoungLang; Ahn, Yu Mi; Blackman, Burchelle; Diederich, Wibke E.; Flaherty, Patrick T.; Georg, Gunda I.; Mossman, Craig J.; Roy, Subho.    Department of Medicinal Chemistry,  University of Kansas,  Lawrence,  KS,  USA.    Abstracts of Papers, 223rd ACS National Meeting, Orlando, FL, United States, April 7-11, 2002  (2002),     ORGN-295.
• Short and efficient chiral pool and RCM approach towards the synthesis of the macrocyclic core of the salicylihalamides.     Georg, Gunda I.; Ahn, Yu Mi; Blackman, Burchelle; Farokhi, Faryar; Flaherty, Patrick T.; Mossman, Craig J.; Roy, Subho; Yang, KyoungLang.    Department of Medicinal Chemistry, University of Kansas,  Lawrence,  KS,  USA.    Chemical Communications (Cambridge)  (2001),   (3),  255-256.
• Progress toward the total synthesis of salicylihalamide A and B.     Georg, Gunda I.; Blackman, Burchelle; Mossman, Craig J.; Yang, KyoungLang; Flaherty, Patrick T..    Department of Medicinal Chemistry,  University of Kansas,  Lawrence,  KS,  USA.    Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000  (2000),     ORGN-808.
• Synthesis and biological evaluation of 10-photoaffinity, 7-radiolabeled paclitaxel analogs.     Flaherty, Patrick T.; Liu, Yanbin; Georg, Gunda I.; Himes, Richard H.    Department of Medicinal Chemistry,  University of Kansas,  Lawrence,  KS,  USA.    Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000  (2000),     MEDI-077.
• The non-mevalonate pathway for isoprenoid biosynthesis: new opportunities for drug design.     Flaherty, Patrick T.; Georg, Gunda I.    University of Kansas,  USA.    Chemtracts  (2000),  13(4),  237-244.  CODEN: CHEMFW  ISSN: 1431-9268.
• Prodrugs for the selective inhibition of monoamine oxidase-B.     Castagnoli, Neal, Jr.; Flaherty, Patrick; Castagnoli, Kay; Wang, You-Xiong.  PCT Int. Appl.  (1998),     40 pp.  CODEN: PIXXD2  WO  9822110  A1  19980528  Designated States W: CA, CN, JP, US.  Designated States RW: AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE.  Patent  written in English.    Application: WO  97-US21230  19971119.  Priority: US  96-31439.  CAN 129:36470    AN 1998:351762  
• Synthesis and biological evaluation of photoaffinity, fluorescent, and radiolabeled paclitaxel analogs.     Flaherty, Patrick T.; Liu, Yanbin; Georg, Gunda I.; Himes, Richard H.    Department Medicinal Chemistry,  University Kansas,  Lawrence,  KS,  USA.    Book of Abstracts, 215th ACS National Meeting, Dallas, March 29-April 2  (1998),     MEDI-175.
• Synthesis of a-substituted N-silyl aminoacetonitriles as N-silyl imine precursors.     Zhang, Yong; Liu, Yanbin; Victory, Sam F.; Flaherty, Patrick T.; Georg, Gunda I.    Department Medicinal Chemistry,  University Kansas,  Lawrence,  KS,  USA.    Book of Abstracts, 215th ACS National Meeting, Dallas, March 29-April 2  (1998),     ORGN-339.
• Compatibility of Various Carbanion Nucleophiles with Heteroaromatic Nucleophilic Substitution by the SRN1 Mechanism.     Wong, Jim-Wah; Natalie, Kenneth J., Jr.; Nwokogu, Godson C.; Pisipati, Jyothi S.; Flaherty, Patrick T.; Greenwood, Thomas D.; Wolfe, James F.    Department of Chemistry and the Harvey W. Peters Research Center for the Study of Parkinson's Disease and Disorders of the Central Nervous System,  Virginia Polytechnic Institute and State University,  Blacksburg,  VA,  USA.    Journal of Organic Chemistry  (1997),  62(18),  6152-6159.
• Synthesis and Selective Monoamine Oxidase B-Inhibiting Properties of 1-Methyl-1,2,3,6-tetrahydropyrid-4-yl Carbamate Derivatives: Potential Prodrugs of (R)- and (S)-Nordeprenyl.     Flaherty, Patrick; Castagnoli, Kay; Wang, You-Xiong; Castagnoli, Neal, Jr.    Department of Chemistry,  Virginia Tech,  Blacksburg,  VA,  USA.    Journal of Medicinal Chemistry  (1996),  39(24),  4756-4761.
• Synthesis and evaluation of N-phenylacetyltrifluoromethane-sulfonamides as anticonvulsant agents.   Flaherty, P. T.; Greenwood, T. D.; Manheim, A. L.; Wolfe, J. F.    Department Chemistry,  Virginia Polytechnic Institute and State University,  Blacksburg,  VA,  USA.    Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28  (1996),     MEDI-056. 
• Synthesis and evaluation of N-(phenylacetyl)trifluoromethane-sulfonamides as anticonvulsant agents.     Flaherty, Patrick T.; Greenwood, Thomas D.; Manheim, Amy L.; Wolfe, James F.    Department of Chemistry,  Virginia Polytechnic Institute and State University,  Blacksburg,  VA,  USA.    Journal of Medicinal Chemistry  (1996),  39(7),  1509-13.
• A-Ring Ortho-Disubstituted Aporphine Derivatives as Potential Agonists or Antagonists at Serotonergic 5-HT1A Receptors.     Cannon, Joseph G.; Flaherty, Patrick T.; Ozkutlu, Ugur; Long, John Paul.    College of Pharmacy,  University of Iowa,  Iowa City,  IA,  USA.    Journal of Medicinal Chemistry  (1995),  38(11),  1841-5. 
• A-ring ortho-disubstituted aporphine derivatives as potential agonists or antagonists at serotonergic 5HT1A receptors.     Flaherty, Patrick Thomas.    Univ. Iowa,  Iowa City,  IA,  USA.  Avail. Univ. Microfilms Int., Order No. DA9334597.    (1993),     164 pp.  From: Diss. Abstr. Int. B 1994, 54(7), 3570.