Aleem Gangjee, Ph.D.
Professor of Medicinal Chemistry
Mylan School of Pharmacy Distinguished Professor

451 Mellon Hall
T 412.396.6070
E gangjee@duq.edu

B. S. (Chemistry)--Indian Institute of Technology
M.S. (Organic Chemistry),--Indian Institute of Technology
Ph.D.--(Medicinal Chemistry)--University of Iowa
PostDoctoral, Biochemistry--University of Iowa
NCI Postdoctoral Trainee, Medicinal Chemistry--SUNY at Buffalo

• 232 Basic Pharmacology (University of Pittsburgh, 1983)
  
• 309 Biochemistry and Nutrition
  
• 310 Analysis of Drug Substances
  
• 313 Medicinal Chemistry & Natural Products
  
• 314 Medicinal Chemistry & Natural Products
  
• 421 Medicinal Chemistry
• 429 Biomedical Sciences and Therapeutics VIII

Graduate Courses Taught (1979 to present)

• 522 Spectral Methods
  
• 523 Advanced Medicinal Chemistry I
  
• 524 Advanced Medicinal Chemistry II
  
• 623 Selected Topics in Medicinal Chemistry
  
• 671 Chemistry of Heterocyclic Compounds
  
• 527 Advanced Medicinal Chemistry
  

• Synthetic Medicinal Chemistry
  
• Computer Assisted Drug Design
  
• Design and Synthesis of Antitumor Agents Related to Folates and Folate Metabolism
  
• Design and Synthesis of Multi-Acting Antitumor Agents
  
• Design and Synthesis of Novel Tubulin Antimitotic Inhibitors
  
• Design and Synthesis of Mono, dual and Multi-Tyrosine Kinase Inhibitors
  
• Heterocyclic Synthesis of Novel Ring Systems
  
• Stereochemistry of Inhibition of Folate Metabolizing Enzymes
  

• Structure-base design and synthesis of:
  Antibacterial and Antitumor Agents Related to Antifolates.
  
• Receptor Tyrosine Kinase Inhibitors as Antitumor Agents.
  
• Dual Thymidylate Synthase/Dihydrofolate Reductase Inhibitors.
  
• Dual and Multi-acting Inhibitors as Antitumor Agents.
  
• Single Agents with Cytotoxic and Cytostatic Activities
  
• Tubulin Inhibitors as Antitumor Agents.
  
• Computer Assisted Drug Design.
  

• Ranked first in the graduating M.S. Class of 1971, Organic Chemistry, Indian Institute of Technology.
• International Student Scholarship, University of Iowa, 1971-75.
• Research Assistantship, Graduate College, University of Iowa, 1971-75.
• Award for Outstanding Academic Achievement Graduate College, University of Iowa, 1973.
• Phi Lambda Upsilon, Chemistry Honor Society, 1975.
• Postdoctoral Trainee Fellowship National Cancer Institute training grant at SUNY, Buffalo, 1976-1979.
• The American Men and Women of Science, 1979.
• Rho Chi, Pharmacy Honor Society, 1980.
• The Society of Sigma XI, 1981.
• Starter Grant, Faculty Research and Scholarship Award, Duquesne University, April 1982.
• The New York Academy of Science, 1982.
• President, Duquesne Sigma Xi Club, 1983.
• Runner-up Duquesne Man of the Year, 1985-86.
• Commencement Speaker, Pharmacy Class of 1988.
• Duquesne University Presidential Award for Faculty Excellence in Scholarship, 1988.
• School of Pharmacy Teacher of the Year Award, 1988.
• Shannon Award, NIH, 1991.
• Who's Who in American Education, 1992.
• National Institutes of Health (NIH) consultant.
• Duquesne University School of Pharmacy Award for Excellence in Research, 1995.
• Who's Who in Medicine and Healthcare, 1996.
• Elected to the American Association for Cancer Research, 1996.
• National Institutes of Health, BNP-1 Special Emphasis Pane Study Sectionl, 1996.
• Duquesne University School of Pharmacy Award for Excellence in Teaching, 1997.
• The only faculty in the School of Pharmacy to receive both the awards for Excellence in Teaching and Research.
• Duquesne University Presidential Award for Faculty Excellence in Teaching, 1997.
• One of three faculty at Duquesne University to receive both the University Presidential Award for Faculty Excellence in Scholarship and Teaching.
• Among the top three authors to publish the most number of papers in The Journal of Medicinal Chemistry for 1995 and two years in a row, 1997 and 1998, of all authors both nationally and internationally.
  
• Awarded twenty US patents.
• World Health Organization invited participant in collaborative research, 1998.
• Granted the title of Mylan School of Pharmacy Distinguished Professor, 1998.
• NIH National Cancer Institute Study Section Experimental Therapeutics I, 1999-2003.
• Chosen as a N.C.P.A. Member's Favorite Professor, 2000.
• Editorial Advisory Board Member, Current Medicinal Chemistry, Anti-Cancer Agents, 2001-present.
• Ad-Hoc Member: National Institutes of Health, Center for Scientific Review, AIDS and Related Research, 2002-2003.
• Ad-Hoc Member: National Institutes of Health, Center for Scientific Review, AIDS and AIDS Related Research Integrated Review Group (AARR), AIDS and AIDS Related Research Study Section, 2003-2004.
• Ad-Hoc Member: National Institutes of Health, Center for Scientific Review, Oncologic Sciences Integrated Review Group, Drug Discovery & Molecular Pharmacology (DMP) Study Section, 2003-2004.
• Editorial Board of Medicinal Chemistry Reviews - Online, 2004-2006.
• Member of The Honor Society of Phi Kappa Phi, 2007.
• Recipient of the President’s Award for Faculty Excellence in Scholarship, September 2008.
• Member: Editorial Advisory Board, Journal of Medicinal Chemistry, 2008-2012.

• Single Agents With Designed Combination Chemotherapy Potential National Institutes of Health, National Cancer Institute (NIH/NCI) American Recovery and Reinvestment Act of 2009 Two years: June 1, 2009 to May 31, 2011   
• Antitumor Antimitotics That Reverse Tumor Resistance NIH, National Cancer Institute (NCI)   Five years:    Feb. 24, 2006  --   Jan. 31, 2011 
• Novel, P. jirovecii Specific Antipneumocystis Agents  NIH,  National Institute of Allergy and Infectious Diseases (NIAID) Four years:    May 15, 2006 to Apr. 30, 2010 
• Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents 
  NIH, National Cancer Institute Five years:    Sept. 26, 2006 to July 31, 2011 

• Gangjee, A.; Li, W.; Kisliuk, R. L.; Cody, V.; Pace, J.; Piraino, J. and Makin, J. Design, Synthesis and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents. J. Med. Chem., 2009, 52, 4892-4902. "http://pubs.acs.org/doi/pdfplus/10.1021/jm900490a. NIHMSID # 133294.
• Deng, Y,; Zhou, X.; Desmoulin, S.K.; Wu, J.; Cherian, C.; Hou, Z.; Matherly, L. H. and Gangjee, A. Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors Over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry. J. Med. Chem., 2009, 52, 2940-2951. http://pubs.acs.org/doi/pdfplus/10.1021/jm8011323. PMID 19371039.
• Gangjee, A.; Adair, O. O.; Pagley, M. and Queener, S. F. N9-Substituted 2,4-Diaminoquinazolines: Synthesis and Biological Evaluation of Lipophilic Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase. J. Med. Chem., 2008, 51, 6195-6200. http://pubs.acs.org/doi/abs/10.1021/jm800694g.
• Gangjee, A.; Qiu, Y.; Li, W. and Kisliuk, R. L. Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine Antifolates. J. Med. Chem., 2008, 51, 5789-5797. http://pubs.acs.org/doi/abs/10.1021/jm8006933.
• Deng, Y.; Wang, Y.; Cherian, C.; Hou, Z.; Buck S. A.; Matherly, L. H. and Gangjee, A. Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors with Antitumor Activity. J. Med. Chem., 2008, 51, 5052-5063.
• Gangjee, A.; Jain, H. D.; Queener, S. F. and Kisliuk, R. L. The Effect of 5-Alkyl Modification on the Biological Activity of Pyrrolo[2,3-d]pyrimidine Containing Classical and Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductase and as Antitumor and/or Antiopportunistic Infection Agents. J. Med. Chem., 2008, 51, 4589-4600.
• Gangjee, A., Namjoshi, O. A.; Yu, J.; Ihnat, M. A.; Thorpe, J. E. and Warnke, L. A. Design, Synthesis and Biological Evaluation of Substituted Pyrrolo[2,3-d]pyrimidines as Multiple Receptor Tyrosine Kinase Inhibitors and Antiangiogenic Agents. Bioorg. & Med. Chem., 2008, 16, 5514-5528.
• Gangjee, A.; Jain, H. D. and Kurup, S. Recent Advances in Classical and Non-classical Antifolates as Antitumor and Antiopportunistic Infection Agents, Part II. Anti-Cancer Agents in Med. Chem., 2008, 8, 205-231.
• Deng, Y.; Hou, Z.; Wang, L.; Cherian, C.; Wu, J.; Gangjee, A. and Matherly, L. H. Role of Lysine 411 in Substrate Carboxyl Group binding to the Human Reduced Folate Carrier, as Determined by Site-directed Mutagenesis and Affinity Inhibition. Mol. Pharmacol., 2008, 73, 1274-1281.
• Gangjee, A.; Li, W.; Yang, J. and Kisliuk, R. L. Design, Synthesis and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors. J. Med. Chem., 2008, 51, 68-76.
• Gangjee, A.; Jain, H. D.; Queener, S. F. and Kisliuk, R. L. The Effect of 5-Alkyl Substitution on Dual Inhibitory Activity Against Dihydrofolate Reductase and Thymidylate Synthase in Pyrrolo[2,3-d]pyrimidines. In the proceedings of the 13th International Symposium on Chemistry & Biology of Pteridines and Folates, 2007, 1, 84-90.
• Gangjee, A.; Jain, H.D. and Kurup, S. Recent Advances in Classical and Non-classical Antifolates as Antitumor and Antiopportunistic Infection Agents, Part I. Anti-Cancer Agents in Med. Chem., 2007. 7, 524-542
• Gangjee, A.; Jain, H.D. and Kurup, S. Recent Advances in Classical and Non-classical Antifolates as Antitumor and Antiopportunistic Infection Agents, Part II. Anti-Cancer Agents in Med. Chem., 2007. In press
• Gangjee, A.; Kurup, S. and Namjoshi, O. A.     Dihydrofolate Reductase as a Target for Chemotherapy in Parasites.    Current Pharm. Design, 2007, 13, 609-639.
• Gangjee, A.; Yu, J.; Copper, J. E. and Smith, C. D.    Discovery of Novel Antitumor Antimitotic Agents That Also Reverse Tumor Resistance.     J. Med. Chem., 2007, 50, 3290-3301.   
• Gangjee, A.; Zeng, Y.; Talreja, T.; McGuire, J. J.; Kisliuk, R. L. and Queener, S. F.    Design and Synthesis of Classical and Nonclassical, 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates.     J. Med. Chem., 2007, 50, 3046-3053
• Gangjee, A.; Jain, H. D.; Phan, J.; Lin, X.; Song, X.; McGuire, J. J. and Kisliuk, R. L.    Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase as Antitumour Agents:   Design, Synthesis and Biological Evaluation of Classical and Nonclassical Pyrrolo[2,3-d]pyrimidine Antifolates.    J. Med. Chem., 2006, 49, 1055-1065.   
• Gangjee, A.; Yang, J. and Queener, S. F.     Novel Nonclassical C9-Methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as Potential Inhibitors of Dihydrofolate Reductase and as Anti-opportunistic Agents.     Bioorganic & Medicinal Chemistry, 2006, 14, 8341-8351. 
• Gangjee, A.; Yang, J.; McGuire, J. J. and Kisliuk, R. L.     Synthesis and Evaluation of a Classical 2,4-Diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as Antifolates.      Bioorganic & Medicinal Chemistry, 2006, 14, 8590-8598.  
• Gangjee, A.; Wang, Y.; Queener, S. F. and Kisliuk, R. L.    Synthesis of 2,6-Diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin-4(3H)-one as Inhibitors of Folate Metabolizing Enzymes.     J. Heterocyclic Chem., 2006, 43, 1523-1531.     
• Gangjee, A.  and Lin, X.     COMFA and COMSIA Analyses of Pneumocystis carinii Dihydrofolate Reductase, Toxoplasma gondii Dihydrofolate Reductase and Rat Liver Dihydrofolate Reductase.    J.  Med.  Chem., 2005, 48, 1448-1469.   
• Gangjee, A.; Jain, H.  D.  and Kisliuk, R.  L.     Novel 2-Amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase.     Bioorg. & Med.  Chem.  Ltrs., 2005, 15, 2225-2230.   
• Gangjee, A.; Jain, H.  D.  and Queener, S.  F.     Design, Synthesis and Biological Evaluation of 2,4-Diamino-6-methyl-5-substituted-pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors.    J.  Heterocyclic Chem., 2005, 42, 589-594.    
• Gangjee, A.; Zeng, Y.; McGuire, J.  J.  and Kisliuk, R.  L.     Synthesis of Classical, Four-carbon-bridged 5-Substituted Furo[2,3-d]pyrimidine and 6-Substituted Pyrrolo[2,3-d]pyrimidine Analogues as Antifolates.    J.  Med.  Chem., 2005, 48, 5329-5336.       
• Gangjee, A.; Zeng, Y.; Ihnat, M.; Warnke, L.  A.; Green, D.  W.; Kisliuk, R.  L.  and Lin, F-T.    Novel 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Multi-receptor Tyrosine Kinase and Dihydrofolate Reductase Inhibitors with Antiangiogenic and Antitumor Activity.    Bioorganic and Medicinal Chemistry, 2005, 13, 5475-5491.      
• Gangjee, A.; Ye, Z. and Queener, S. F.     Synthesis of Three Carbon Atom Bridged 2,4-Diaminopyrrolo[2,3-d]pyrimidines as Nonclassical Dihydrofolate Reducatse Inhibitors.    J. Heterocyclic Chem., 2005, 42, 1127-1133.   
• Gangjee, A.; Lin, X.; Kisluk, R. L. and McGuire, J. J.      Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic Acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic Acid as Dual Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase, and as Potential Antitumor Agents.      J. Med. Chem., 2005, 48, 7215-7222
• Cody, V.; Luft, J. R.; Pangborn, W.; Gangjee, A. and Queener, S. F. Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry. Acta Cryst., 2004, D60, 646-655.
  
• Li, W.; Favelyukis, S.; Yang, J.; Zeng, Y.; Yu, J.; Jain, H.; Gangjee, A. and Miller, W. T. Inhibition of Insulin-like Growth Factor I Receptor Autophosphorylation by Novel 6-5 Ring-fused Compounds. Biochem. Pharm., 2004, 68, 145-154.
  
• Gangjee, A.; Lin, X. and Queener, S. F. Design, Synthesis and Biological Evaluation of 2,4-Diamino-5-methyl-6-substituted Pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors. J. Med. Chem., 2004, 47, 3689-3692.
  
• Gangjee, A. U.S. Patent No. 6,770,652. Multiple Acting Anti-Angiogenic and Cytotoxic Compounds and Methods for Using the Same. August 3, 2004.
  
• Gangjee, A. and Jain, H. D. Antifolates – Past, Present and Future. Curr. Med. Chem. - Anti-Cancer Agents, 2004, 4, 405-410.
  
• Gangjee, A.; Qiu, Y. and Kisliuk, R. L. Synthesis of Classical and Nonclassical 2-Amino-4-oxo-6-benzythieno[2,3-d]pyrimidines as Potential Thymidylate Synthase Inhibitors. J. Heterocyclic Chem., 2004, 41, 941-946.
  
• Gangjee, A.; Zeng, Y.; McGuire, J. J.; Mehraein, F. and Kisliuk, R. L. Synthesis of Classical, Three Carbon Bridged 5-Substituted Furo[2,3-d]pyrimidine and 6-Substituted Pyrrolo[2,3-d]pyrimidine Analogues as Antifolates. J. Med. Chem., 2004, 47, 6893-6901.
  
• Gangjee, A.; Jain, H. D.; McGuire, J. J. and Kisliuk, R. L. Benzoyl Ring Halogenated Classical 2-Amino-6-methyl-3,4-dihydro-4-oxo-5-substituted Thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine Antifolates as Inhibitors of Thymidylate Synthase and as Antitumor Agents. J. Med. Chem., 2004, 47, 6730-6739.
  
• Gangjee, A.; Jain, H. D.; Phan, J. and Kisliuk, R. L. Synthesis of 2-Amino-4-oxo-5-substitutedbenzylthio-pyrrolo[2,3-d]pyrimidines as Potential Inhibitors of Thymidylate Synthase. J. Heterocyclic Chem., 2004, 42, 165-168.

• Gangjee, A.; Pavana, R. K. and Ihnat, M. A. Design and Synthesis of 7-(3,4,5-Trimethoxybenzyl)-N4-substituted Phenyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-diamines as Receptor Tyrosine Kinase Inhibitors. Presented at the 238th American Chemical Society National Meeting in Washington DC, August 16-20, 2009. MEDI 366.
• Gangjee, A.; Zhao, Y, and Ihnat, M. A. Novel (E)-9-benzylidene-N4-substituted-9H-indeno[2,1-d]pyrimidine-2,4-diamines as Multiple RTK Inhibitors. Presented at the 238th American Chemical Society National Meeting in Washington DC, August 16-20, 2009. MEDI 141.
• Gangjee, A.; Zaware, N.; Yang, J.; Devambatla, R. K. V. and Kisliuk, R. L. Design, Synthesis and Biological Evaluation of 2-Amino-5-substituted-3,9-dihydro-4H-pyrimido[4,5-b]indol-4-ones as Potent Inhibitors of Toxoplasma gondii Thymidylate Synthase. Presented at the 238th American Chemical Society National Meeting in Washington DC, August 16-20, 2009. MEDI 117.
• Gangjee, A.; Wang, L. and Kisliuk, R. L. Synthesis of 2,4-Diamino-pyrimido[4,5-b]indoles as Inhibitors of Dihydrofolate Reductase. Presented at the 238th American Chemical Society National Meeting in Washington DC, August 16-20, 2009. MEDI 72.
• Gangjee, A.; Zhang, X.; Li, W.; Zeng, Y, and Kisliuk, R. L. Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylfuro[2,3-d]pyrimidine Antifolates as Thymidylate Synthase Inhibitors. Presented at the 238th American Chemical Society National Meeting in Washington DC, August 16-20, 2009. MEDI 70.
• Gangjee, A.; Devambatla, R. K. V.; Zaware, N. and Ihnat, M. A. Efficient Large Scale Synthesis of 5-(Phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamine: A Potent Dual Inhibitor of Thymidylate Synthase and Multiple Receptor Tyrosine Kinases. Presented at the 42nd Annual Mid-Atlantic Graduate Student Symposium (MAGSS) in Medicinal Chemistry, Toledo, OH, June 21-23, 2009.
• Cody, V.; Pace, J.; Piraino, J.; Queener, S. F. and Gangjee, A. Conformational Flexibility in the binding of a thieno[2,3-d]pyrimidine Antifolate to Human Dihydrofolate Reductase Active Site Mutants. Presented at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver, CO, April 18-22, 2009. Abstract No: 5361.
• Cody, V.; Freindorf, M.; Furlani, T.; Queener, S. F. and Gangjee, A. Correlations of the Kinetic Properties and Computational Qm/MM Modeling of Potent Dihydrofolate Reductase Inhibitors. Presented at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver, CO, April 18-22, 2009. Abstract No: 2458.
• Desmoulin, S. K.; Wang, Y.; Wu, J.; Hou, Z.; Cherian, C.; Gangjee, A. and Matherly, L. H. Discovery of a Glycinamide Ribonucleotide Formyltransferase Inhibitor with Solid Tumor Selectivity via its Transport by the Proton-coupled Folate Transporter. Presented at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver, CO, April 18-22, 2009. Abstract No: 1684.
• Gangjee, A.; Zaware, N.; Kisliuk, R. L. and Ihnat, M. A. The Design of Combination Chemotherapeutic Potential in Single Agents. Presented at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver, CO, April 18-22, 2009. Abstract No: 656.
• Wang, L.; Desmoulin, S. K.; Polin, L.; Cherian, C.; Deng, Y.; Matherly, L. H. and Gangjee, A. The Design, Synthesis and Preclinical Evaluation of Selective FR and PCFT Substrates With Potent GARFTase Inhibitory Activity as Antitumor Agents. Invited podium presentation at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver, CO, April 18-22, 2009. Abstract No: 1918.
• Gangjee, A.; Zhao, Y. and Ihnat, M. A. Novel N4-Phenyl Substituted Tricyclic Indeno[1,2-d]pyrimidines as Tyrosine Kinase Inhibitors and Antiangiogenic Agents. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 219.
• Gangjee, A.; Zaware, N. and Ihnat, M. A. Design, Synthesis and Evaluation of 5-Chloro-N4-substituted Phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as Potential Inhibitors of Multiple Receptor Tyrosine Kinases. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 226.
• Gangjee, A.; Zhou, X.; Li, W. and Kisliuk, R. L. Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-isopropyl Thieno[2,3-d]pyrimidine Antifolates as Potent Thymidylate Synthase Inhibitors. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 95. Received a $1,000 MEDI Travel Grant.
• Gangjee, A. and Zhao, S. Design, Synthesis and Biological Evaluation of 2-Desamino-4-alkyl-5-[(substituted phenyl)ethyl]-7substituted Pyrrolo[2,3-d]pyrimidines as Antitumor Antimitotic Agents. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 94.
• Gangjee, A.; Zhang, X.; Zhou, X. and Kisliuk, R. L. Synthesis of 2-Methyl-4-oxo-benzo[4,5]thieno[2,3-d]pyrimidine as TS Inhibitor. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 93.
• Gangjee, A.; Wang, Y.; Deng, Y.; Cherian, C.; Hou, Z. and Matherly, L. H. The Importance of the Glutamate Moiety for Folate Receptor Targeting and GARFTase Inhibitory Activity in Classical Pyrrolo[2,3-d]pyrimidine Antifolates. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 65.
• Gangjee, A.; Wang, L.; Matherly, L. H.; Deng, Y. and Kisliuk, R. L. Synthesis of Classical 6-Substituted Pyrrolo[2,3-d]pyrimidines as GARFTase Inhibitors With Folate Receptor (FR) Specificity and Antitumor Activity. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 64.
• Gangjee, A.; Raghavan, S.; Li, W.; Queener, S. F. and Cody, V. Synthesis and Biological Evaluation of 2,4-Diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as Inhibitors of Pneumocystis jirovecii and Toxoplasma gondii Dihydrofolate Reductase. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 63. Received a $1,000 MEDI Travel Grant.
• Gangjee, A. Design of Combination Chemotherapeutic Potential in Single Agents. Seminar presentation, Department of Chemistry, Bayer School of Natural and Environmental Sciences, Duquesne University, Pittsburgh, PA, March 20, 2009.
• Gangjee, A. Synthesis and Evaluation of Folate Receptor Specific Antitumor Agents. Invited podium presentation at the 2nd International Meeting on Folate Receptors and Carriers, Villa Vigoni, Como, Italy, Oct. 26-30, 2008.
• Gangjee, A.; Li, W.; Qiu, Y.; Kisliuk, R. L. and Queener, S. F. Design, Synthesis and Biological Evaluation of 2,4-Diamino-5-methyl-6-substituted-thieno[2,3-d]pyrimidine: a Novel Classical Antifolate with Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitory Activity as Potential Antitumor Agent. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 130.
• Gangjee, A.; Zhao, Y. and Ihnat, M. A. Novel 4-Phenylsulfanyl Substituted Tricyclic Indeno[2,1-d]pyrimidines as Tyrosine Kinase Inhibitors and Antiangiogenic Agents. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 156.
• Gangjee, A.; Zhang, X.; Kisliuk, R. L. and Queener, S. F. Design, synthesis and Evaluation of 6-6 Fused Bicyclic Nonclassical Pneumocystis jirovecii (pj) and Toxoplasma gondii (tg) Dihydrofolate Reductase (DHFR) Selective Inhibitors. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 341.
• Gangjee, A.; Kurup, S. and Ihnat, M. A. Synthesis and Biological Activity of 2-Desamino-4-substituted Anilino-6-substituted Phenylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 362.
• Gangjee, A.; Zaware, N.; Yang, J. and Ihnat, M. A. N4-(3-Bromophenyl)-7-(substitutedbenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,3-diamines as Novel Potent Multiple Receptor Tyrosine Kinase Inhibitors. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 373.
• Gangjee, A.; Zhou, X.; Deng, Y,; Matherly, L. H. and Kisliuk, R. L. Classical 6-Substituted Thieno[2,3-d]pyrimidines as GARFTase Inhibitors with Folate Receptor (FR) Specificity and Antitumor Activity. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 157.
• Gangjee, A.; Zhao, Y.; Ihnat, M. A. and Kisliuk, R. L. Novel Tricyclic Indeno[2,1-d]pyrimidines with Dual Cytostatic and Cytotoxic Activities as Antitumor Agents. Presented at the American Association for Cancer Research (AACR) Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract no. 1295.
• Gangjee, A.; Wang, Y.; Deng, Y.; Cherian, C.; Hou, Z. and Matherly, L. H. Discovery of ?-Folate Receptor Specific GARFTase Inhibitors as Selective Antitumor Agents. Presented at the American Association for Cancer Research (AACR) Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract no. 1309.
• Cody, V.; Pace, J. B.; Gangjee, A.; Lin, L.; Zeng, L. and Queener, S. F. Alternate Binding Modes Observed for E- and Z-Isomers of 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH in Mouse Dihydrofolate Reductase. Presented at the American Association for Cancer Research (AACR) Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract no. 3188.
• Deng, Y.; Wang, Y.; Cherian, C.; Hou, Z.; Taub, J. W.; Gangjee, A. and Matherly, L. H. A Series of Novel 6-Substituted 2-Amino-4-oxopyrrolo[2,3-d]pyrimidine Antifolates Specifically Transported by Folate Receptors and Targeting the de novo Purine Biosynthesis Pathway. Presented at the American Association for Cancer Research (AACR) Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract no. 3288.
• Gangjee, A.; Smith, C. D. and Zaware, N. Synthesis and Evaluation of Potential Antitumor Antimitotics That Also Reverse Tumor Resistance. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 107.
• Gangjee, A.; Kurup, S. and Smith, C. D. Synthesis of 7-Substituted Benzyl-5-[(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as Microtubule Inhibitors. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 074.
• Gangjee, A.; Zhang, X. and Smith, C. D. Synthesis of Substituted Pyrrolo[2,3-d]pyrimidines with N7 Chain Length Difference as Novel Antitumor Antimitotic Agents That Also Reverse Tumor Resistance. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 108.
• Gangjee, A.; Zhou, X.; Zhang, X. and Kisliuk, R. L. Synthesis of Benzo[4,5]thieno[2,3-d]pyrimidine as Potential Dual TS and DHFR Inhibitor. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 109.
• Gangjee, A.; Wang, L. and Kisliuk, R. L. Synthesis of Pyrimido[4,5-b]indoles as Selective Inhibitors of Toxoplasma gondii Dihydrofolate Reductase. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 224.
• Gangjee, A.; Li, W. and Queener, S. F. Design, Synthesis and Biological Evaluation of 5-Substituted-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-diamines as Dihydrofolate Reductase Inhibitors. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 297.
• Gangjee, A. From the Design of Antifolates to Tyrosine Kinase Inhibitors and Beyond. Plenary presentation at the 15th Mainzer Forum “Medicinal Chemistry,” Kinase Inhibitors - From Biology to Clinic, Johnannes Gutenberg Universität, Institute of Pharmacy, Mainz, Germany, September 28, 2007.
• Gangjee, A.; Namjoshi, O. A.; Keller, S. N. and Smith, C. D.   2-Amino-4-methyl-5-phenylethylsubstituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as Novel Antitumor Antimitotic Agents That Also Reverse tumor Resistance.    Presented at the 233rd American Chemical Society National Meeting, Chicago, IL, March 25-29, 2007.     MEDI 169. 
• Gangjee, A.; Kurup, S.; Ihnat, M. A. and Green D.   Synthesis and Biological Activity of 2-Amino-4-substituted Anilino-6-substituted Phenylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases.   Presented at the 233rd American Chemical Society National Meeting, Chicago, IL, March 25-29, 2007.    MEDI 113. 
• Deng, Y.; Zhanjun, H.; Cherian, C.; Hou, Z.; Wu, J.; Wang, L.; Gangjee, A. and Matherly, L. H.    Identification of Human Reduced Folate Carrier (hRFC) Substrate Binding Sites by Site-directed Mutagenesis and Affinity Labeling Strategies.    Podium presentation at the American Association for Cancer Research (AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007.     Abstract no. 5731.
• Gangjee, A.; Yang, J.; Li, W. and Kisliuk, R. L.     Design, Synthesis and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methyl-pyrrolo[3,2-d]pyrimidines as Potential Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors.     Presented at the American Association for Cancer Research (AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007.    Abstract no.  2411. 
• Gangjee, A.; Wang, L.; Deng, Y.; Cherian, C.; Matherly, L. H. and Kisliuk, R. L.    Synthesis of 2,4-Diamino-5-substituted-furo[2,3-d]pyrimidines as Potential Substrates for the RFC and as Classical Antifolate Analogs.    Presented at the American Association for Cancer Research (AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007.    Abstract no. 4865.  
• Gangjee, A.; Zhao, Y.; Smith, C. D. and Keller, S. N.     Design and Synthesis 7-Substituted-benzyl-5-[2-(2-methyoxyl-phenyl)-ethyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine as Microtubule Inhibitors.    Presented at the American Association for Cancer Research (AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007.    Abstract no.   3958. 
• Gangjee, A.; Zaware, N.; Keller, S. N. and Smith, C. D.     Antitubulin 7-Benzyl-4-methyl-5-(2-substituted phenyl ethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amines as Potential Antitumor Agents and P-glycoprotein Modulators.      Presented at the 40th Annual Mid-Atlantic Graduate Student Symposium (MAGSS), West Virginia University, Department of Basic Pharmaceutical Sciences, C. Eugene Bennett Department of Chemistry, Morgantown, WV, June 10-12, 2007.    
• Gangjee, A.; Zhao, Y.; Smith, C. D. and Keller, S. N.    Substituted Pyrrolo[2,3-d]pyrimidines as Antitumor Antimitotic Agents With Tumor Resistance Reversing Attributes.    Presented at the 40th Annual Mid-Atlantic Graduate Student Symposium (MAGSS), West Virginia University, Department of Basic Pharmaceutical Sciences, C. Eugene Bennett Department of Chemistry, Morgantown, WV, June 10-12, 2007.      
• Gangjee, A.; Namjoshi, O.; Zhao, Y. and Smith, C. D.     Synthesis and Evaluation of Substituted Pyrrolo[2,3-d]pyrimidines as Antitumor Antimitotics That Also Reverse Tumor Resistance.    Podium presentation at the 6th Asian Federation for Medicinal Chemistry (AFMC) International Medicinal Chemistry Symposium, Istanbul, Turkey, July 8-11, 2007.    OP-60. 
• Gangjee, A.; Jain, H. D.; Queener, S. F. and Kisliuk, R. L.   Non-classical 5-Alkyl-6-substitutedarylthiopyrrolo[2,3-d]pyrimidines as Potent and Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors.   Presented at the 231st American Chemical Society (ACS) National Meeting,  Atlanta, GA, March 26-30, 2006.   
• Gangjee, A.; Raghavan, S. and Ihnat, M. A.     Synthesis of 2-Amino-4-substituted-6-arylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases.  Presented at the 231st American Chemical Society (ACS) National Meeting,  Atlanta, GA, March 26-30, 2006.   
• Gangjee, A. and Lin, X.     CoMFA Analysis of tgDHFR and rlDHFR Based on Antifolates with 6-5 Fused Ring System.     Presented at the 231st American Chemical Society (ACS) National Meeting,  Atlanta, GA, March 26-30, 2006.   
• Celikkaya, H.; Jain, H. D.; Zeng, Y.; Yang, J.; Lin, X.; Gangjee, A.; Bertino, J. R. and Abali, E. E.   Novel Antifolates That Do Not Upregulate Thymidylate Synthase and Dihydrofolate Reductase Levels.  Presented at the 97th American Association for Cancer Research (AACR) Annual Meeting, Washington, DC, April 1-5, 2006.    Poster No. 552. 
• Gangjee, A.; Namjoshi, O. A.; Ihnat, M. A. and Miller, W. T.     Effect of a 2-Amino Group on Receptor Tyrosine Kinase Inhibition and Antiangiogenic Activity of 4-Anilinosubstituted Pyrrolo[2,3-d]pyrimidines.    Presented at the 97th American Association for Cancer Research (AACR) Annual Meeting, Washington, DC, April 1-5, 2006.    Poster No. 243.      
• Gangjee, A.; Zaware, N.; Yang, J. and Ihnat, M. A.     7-Arylmethyl Pyrrolo[2,3-d]pyrimidines as Receptor Tyrosine Kinase Inhibitors:   Design, Synthesis and Biological Evaluation.    Presented at the 97th American Association for Cancer Research (AACR) Annual Meeting, Washington, DC, April 1-5, 2006.    Poster No. 5077.   
• Gangjee, A.; Namjoshi, O. A.; Ihnat, M. A. and Miller, W. T.    Effect of a 2-Amino Group on Receptor Tyrosine Kinase Inhibition and Antiangiogenic Activity of 4-Anilinosubstituted Pyrrolo[2,3-d]pyrimidines.   Presented at the 39th Annual Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry (MAGSS) at Ohio State University, Columbus, OH, June 18-20, 2006.   
• Gangjee, A.; Raghavan, S. and Ihnat, M. A.    Synthesis of 2-Amino-4-substituted-6-arylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor tyrosine Kinases.    Presented at the 39th Annual Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry (MAGSS) at Ohio State University, Columbus, OH, June 18-20, 2006.   
• Gangjee, A., Namjoshi, O. A.; Ihnat, M. A.; Warnke, L. A. and Thorpe, J. E.    Design and Synthesis of 2-Amino-4-anilino-6-substituted Pyrrolo[2,3-d]pyrimidines as Antiangiogenic Agents.    Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006.  MEDI 432.    
• Gangjee, A.; Yu, J.; Keller, S. N. and Smith, C. D.    Discovery of Novel Antitumor Antimitotic Agents that Also Reverse Tumor Resistance.   Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006.   MEDI 142.  
• Gangjee, A.; Jain, H. D.; Queener, S. F. and Kisliuk, R. L.     Non-classical 5-Aryl-furo[2,3-d]pyrimidines and 6-Aryl-pyrrolo[2,3-d]pyrimidines as Potential Dihydrofolate Reductase and/or Thymidylate Synthase Inhibitors.   Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006.    MEDI 140.    
• Gangjee, A.; Zhou, X.; Kisliuk, R. L. and Queener, S. F.    2,4-Dimino-6-aryl Thieno[2,3-d]pyrimidines as Potential Dihydrofolate Reductase Inhibitors.   Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006.    MEDI 138.  
• Gangjee, A.; Wang, L.; Matherly, L. H.; Deng, Y. and Kisliuk, R. L.    Synthesis of Classical diaminofuro[2,3-d]pyrimidine Analogs as Antifolates.    Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006.    MEDI 143.
• Gangjee, A.; Li, W.; Ihnat, M.; Warnke, L. A.; Thorpe, J. E.; Miller, W. T. and Kisliuk, R. L.     Design, Synthesis and Evaluation of Novel 5-Substituted, 2,4-Diaminofuro[2,3-d]pyrimidines as Single Agent Multireceptor Tyrosine Kinase and Dihydrofolate Reductase Inhibitors.    Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006.     MEDI 141. 
• Gangjee, A.; Lin, L.; Ihnat, M.; Warnke, L. A.; Thorpe, J. E. and Kisliuk, R. L.    Novel-5-Substituted 2,4-diaminofuro[2,3-d]pyrimidines as Potential Multi-receptor Tyrosine Kinases and Dihydrofolate Reductase Inhibitors in Single Molecules.    Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006.  MEDI 139.   
• Gangjee, A.; Lin, X.; Biondo, L. R. and Queener, S. F.    Design and Synthesis of a Novel Nanomolar Inhibitor of Toxoplasma Gondii Dihydrofolate Reductase, Its Salt Form and Analogues.    Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006.  MEDI 363.   
• Gangjee, A.; Ye, Z.; Kisliuk, R. L. and Queener, S. F.   Synthesis and Design of 2,4-Diamino-6-substituted-pyrido[3,2-d]pyrimidines as Dihydrofolate Reductase Inhibitors from Opportunistic Pathogens.     Presented at the 229th American Chemical Society National Meeting, San Diego, CA, March 13-17, 2005.    MEDI 353.
• Gangjee, A.; Li, W.; Ihnat, M. A.; Green, D.; Kisliuk, R. L. and Miller, W. T.    Novel 5-Substituted, 2,4-Diaminofuro[2,3-d]pyrimidines as Potential Multi-receptors Tyrosine Kinase and Dihydrofolate Reductase Inhibitors.    Presented at the 229th American Chemical Society National Meeting, San Diego, CA, March 13-17, 2005.     MEDI 112.
• Gangjee, A.; Namjoshi, O. A.; Ihnat, M. A.; Green, D. and Miller, W. T.   Design, Synthesis and Biological Activities of 2-Amino-4-anilino Substituted-6-arylethyl Pyrrolo[2,3-d]pyrimidines as Receptor Tyrosine Kinase Inhibitors and Antiangiogenic Agents.     Presented at the 229th American Chemical Society National Meeting, San Diego, CA, March 13-17, 2005.   MEDI 114.
• Gangjee, A.; Zaware, N.; Ihnat, M. A.; Green, D. and Miller, W. T.    Novel 2-Amino-4-anilino Substituted-7-arylmethyl Pyrrolo[2,3-d]pyrimidines as Receptor Tyrosiine Kinase Inhibitors and Antiangiogenic Agents.     Presented at the 229th American Chemical Society National Meeting, San Diego, CA, March 13-17, 2005.     MEDI 115. 
• Gangjee, A.; Jain, H.; Queener, S. F. and Kisliuk, R. L.    Design and Synthesis of N-[4-(2,4-diamino-5-propyl-7H-pyrrolo[2,3-d]pyrimidin-6-ylsulfanyl)-benzoyl]-L-glutamic Acid as a Potent Inhibitor of Dihydrofolate Reductase and as an Antitumor Agent.   Presented at the 229th American Chemical Society National Meeting, San Diego, CA, March 13-17, 2005.     MEDI 491. 
• Gangjee, A.; Zhao, Y.; Ihnat, M.  A.; Green, D.  and Miller, W.  T.    Synthesis of 2-Amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as Tyrosine Kinase Inhibitors and Antiangiogenic Agents.     Presented at the 96th American Association for Cancer Research (AACR) Annual Meeting, Anaheim, CA, April 16-20, 2005.   
• Gangjee, A.; Kurup, S.; Ihnat, M.  A.; Green, D.  and Miller, W.  T.    Synthesis and Biological Activity of 2-Amino-4-substitutedanilino-6-(2,4-dichloro)phenylmethyl-pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases.    Presented at the 96th American Association for Cancer Research (AACR) Annual Meeting, Anaheim, CA, April 16-20, 2005.   
• Gangjee, A.; Jain, H.  D.; Kisliuk, R.  L.  and Queener, S.  F.     Design and Synthesis of N-[4-[(2,4-Diamino-5-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-6-ylsulfanyl)-bensoyl]-L-glutamic Acid as a Potent Inhibitor of Dihydrofolate Reductase and as an Antitumor Agent.    Presented at the 13th International Symposium on Chemistry and Biology of Pteridienes and Folates, Amsterdam, The Netherlands, June 20-24, 2005.   P-09. 
• Gangjee, A.; Jain, H.  D.  and Kisliuk, R.  L.     Synthesis of a Classical N-[4-[(2,6-dimethyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-ylsulfanyl)-benzoyl]-L-glutamic Acid as a Potential Inhibitor of Thymidylate Synthase and Antitumor Agent.     Presented at the 13th International Symposium on Chemistry and Biology of Pteridienes and Folates, Amsterdam, The Netherlands, June 20-24, 2005.    P-10.   
• Gangjee, A.; Jain, H.  D.; Lin, X.; Zeng, Y.; McGuire, J.  J.  and Kisliuk, R.  L.     The Effect of 5-Alkyl Substitution on Dual Inhibitory Activity Against DHFR and TS in Pyrrolo[2,3-d]pyrimidines.     Podium presentation at the 13th International Symposium on Chemistry and Biology of Pteridienes and Folates, Amsterdam, The Netherlands, June 20-24, 2005.     Abstract number O04-02.  
• Gangjee, A. Design of Single Molecules With Multimechanisms of Action. Presented at the Spring 2004 Seminar, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA , Feb. 24, 2004.
• Gangjee, A.; Kurup, S.; Ihnat, M. A. and Williams, D. E. Synthesis and Biological Activity of 2-Amino-4-substituted Anilino-6-substituted Phenylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 95th American Association for Cancer Research Annual Meeting, Orlando, FL, Mar. 27-31, 2004.
• Gangjee, A.; Qiu, Y. and Kisliuk, R. L. Design and Synthesis of N-[4-[(2-Amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic Acid as a Classical Thymidylate Synthase Inhibitor and as an Antitumor Agent. Presented at the 95th American Association for Cancer Research Annual Meeting, Orlando, FL, Mar. 27-31, 2004.
• Gangjee, A.; Jain, H. D.; McGuire, J. J.; Chu, E. and Kisliuk, R. L. Design and Synthesis of Classical and Nonclassical 6-Ethyl-5-arylthio-substituted Pyrrolo[2,3-d]pyrimidines as Inhibitors of Thymidylate Synthase and as Antitumor Agents. Presented at the 227th American Chemical Society National Meeting, Anaheim, CA, Mar. 28 - Apr.1, 2004.
• Gangjee, A.; Namjoshi, O. A.; Ihnat, M. A. and Kamat, S. Design and Synthesis of 2-Amino-4-anilino Substituted -6-phenylethylpyrrolo[2,3-d]pyrimidines as Receptor Tyrosine Kinase Inhibitors. Presented at the 227th American Chemical Society National Meeting, Anaheim, CA, Mar. 28 - Apr.1, 2004.
• Gangjee, A. Antitumor Agents: Design and Synthesis. Presented at the Tripartite Symposium at Duquesne University, sponsored by the Society for Analytical Chemists of Pittsburgh, the Spectroscopy Society of Pittsburgh and the American Chemical Society, Pittsburgh, PA, Apr. 3, 2004.
  
• Gangjee, A.; Kurup, S.; Ihnat, M. A. and Williams, D. E. Design, Synthesis and Biological Evaluation of 2-Amino-4-substituted Anilino-6-substituted Phenylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 37th Annual Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry, Purdue University, West Lafayette, IN. June 17-19, 2004.
  
• Gangjee, A.; Qiu, Y. and Kisliuk, R. L. Design and Synthesis of N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-gluatmic Acid as a Classical Thymidylate Synthase Inhibitor and as an Antitumor Agent. Presented at the 37th Annual Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry, Purdue University, West Lafayette, IN. June 17-19, 2004.
  
• Gangjee, A.; Jain, H. D.; Queener, S. F. and Kisliuk, R. L. Design and Synthesis of N-[4-[(2,4-diamino-5-methylfuro[2,3-d]pyrimidin-6-yl)thio]benzoyl]-L-glutamic Acid as a Classical Dual Inhibitor of TS and DHFR. Presented at the 228th American Chemical Society National Meeting, Philadelphia, PA, August 22-26, 2004.
  
• Gangjee, A. and Lin, X. CoMFA and CoMSIA Analyses of Pneumocystis carinii, Toxoplasma gondii and Rat Liver Dihydrofolate Reductase (DHFR) Inhibitors. Presented at the 228th American Chemical Society National Meeting, Philadelphia, PA, August 22-26, 2004.
  
• Gangjee, A.; Qiu, Y. and Ihnat, M. A. Design and Synthesis of 2-Amino-4-(3-bromoanilino)-6-substituted Benzylthieno[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 228th American Chemical Society National Meeting, Philadelphia, PA, August 22-26, 2004.

• Rho Chi, Pharmacy Honor Society
  
• Phi Lambda Upsilon, Chemistry Honor Society
• American Association of Pharmaceutical Scientists
• American Chemical Society, Division of Medicinal Chemistry
• American Chemical Society, Division of Organic Chemistry
• American Chemical Society
• Sigma XI, the Scientific Research Society (President,Duquesne University, 1983)
• New York Academy of Sciences
• American Men and Women of Science
• Who's Who in American Education
• American Heart Association
• American Association of Cancer Research
• American Association for the Advancement of Science