1998 PharmD eq. (Diplomirani Farmaceut), Belgrade University, Serbia
Thesis advisor: Prof. Dusan Malesev
Thesis Title: Application of IR Spectroscopy in Drug Analysis
2005 Ph.D. (Pharmaceutical Sciences), University of Pittsburgh, Pittsburgh, PA, USA
Thesis advisors: Prof. Billy W. Day and Prof. Peter Wipf
Thesis Title: Design, Synthesis and Biological Evaluation of New Agents Targeting Estrogen Receptor-Alpha and –Beta
2006 Postdoctoral Research Associate, Scripps Florida, Jupiter, Florida, USA
Project: Highthroughput screening cell based assay development
Advisor: Dr. Kendall Nettles
2009 Research Biologist, Carnegie Mellon University, Pittsburgh, PA, USA
Project: 19F MRI reagent development – synthesis, formulation and biological testing
Advisor: Prof. Eric T. Ahrens
Research Interests
Design, synthesis, formulation and biological testing of multifunctional nanoreagents with focus on molecular imaging and drug delivery. Fluorine chemistry applied to design and synthesis of nanoparticles. Rational design of drug delivery vehicles for DNA, RNA, and small molecules in cancer and inflammation disease models. Studying inflammation and breast cancer using modern imaging techniques in vitro and in vivo. Studying effects of cancer therapeutics on the immune system.
Current Grant Support
2009-2010 1R41EB009618 - 01A1 Title: “Dual Mode Nanoemulsions for 19F MRI and Fluorescence Detection” Role: Principal Investigator
Funding History
2008-2013 - P41 EB001977-21 NMR Center Grant (Program Director Prof. Chen Ho), Project TRD3, Project Leader: Prof. Alan S. Waggoner, PhD Title: “Cell Labeling Chemistry to Make In Vivo MRI a Practical Method”
Role: Investigator
2004-2005 - BC030739 Title: “Design, Synthesis and Biological Evaluation of Focused Combinatorial Libraries of Antiestrogens” DOD Breast Cancer Predoctoral Fellowship
Role: Principal Investigator
Honors and Awards
2004 Graduate Student Excellence Award, School of Pharmacy, Univ. of Pittsburgh, Pittsburgh, PA 2001
Jewish Health Care Foundation - CORO Health Sciences Fellowship, Pittsburgh, PA
Publications and Patents
Janjic, J.M., Ahrens, E.T. “Fluoropolymer compositions and methods for producing cellular labels for nuclear magnetic resonance techniques” PCT Int. Appl. 2009, WO 2009009105 A2 20090115
Kadayakkara, D.K.K.; Beatty, P; Janjic, J.M.; Turner, M.; Ahrens, E.; Finn, O. “Inflammation driven overexpression of the hypoglycosylated abnormal MUC1 links inflammatory bowel disease (IBD) and pancreatitis” Pancreas 2009, accepted
Srinivas, M.; Turner, MS; Janjic, J.M.; Morel, P.A.; Laidlaw, D.H.; Ahrens, E.T. “In vivo cytometry of antigen specific T-cells using 19F MRI” Magnetic Resonance in Medicine, 2009, 62(3), 747-53
Sarachine, M.J.; Janjic, J.M.; Wipf, P; Day, B.W. “Biphenyl C-cyclopropylalkylamides as new scaffolds for targeting estrogen receptor ?” Bioorg. Med. Chem. Lett. 2009, 19, 2404-2408.
Janjic, J.M.; Ahrens, E.T. “Fluorine-containing nanospheres for MRI” Advanced Reviews, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2009, 1 (5), 492-501
Janjic, J.M.; Srinivas, M.; Kadayakkara, D.K.K.; Ahrens, E.T. “Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection”, J. Am. Chem. Soc. 2008, 130, 2832-2413.
Wipf, P.; Gong, H.; Janjic, J.M.; Li, S.; Day, B.W.; Xie, W. “New Opportunities for Pregnane X Receptor (PXR) Targeting in Drug Development. Lessons from Enantio- and Species-Specific PXR Ligands Identified from A Discovery Library of Amino Acid Analogues” Mini Rev. Med. Chem. 2007, 7, 617-625
Poloyac, S.M.; Rohan, L.C.; Janjic, J.M.; Gibbs, R.B.; Kroboth, P.D.; Smith, R.B.; “GEAR-UP (Graduate Education And Research at the University of Pittsburgh) A Program for Educating Students about Pharmaceutical Research,” Am J. Pharm. Ed., 2005, 69, 91-97.
Wipf, P.; Coleman, C.M.; Janjic, J.M.; Iyer, P.S.; Fodor, M.D.; Shafer, Y. A. Stephenson, C.R. J.; Kendall, C.; Day, B.W. “Microwave-Assisted “Libraries from Libraries” Approach toward the Synthesis of Allyl- and C-Cyclopropylalkylamides,” J. Comb. Chem., 2005, 7, 322-330.
Janjic, J.M.; Mu, Y. ; Kendall, C.; Stephenson, C.R. J.; Balachandran, R.; Raccor, B. S. ; Lu, Y.; Zhu, G.; Xie, W.; Wipf, P.; Day, B. W. “New Antiestrogens from a Library Screen of Homoallylic Amides, Allylic Amides and C-Cyclopropylalkylamides,” Bioorg. Med. Chem., 2005, 13, 157-164.
Wipf P.; Janjic J.M.; Stephenson C.R. “Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation-transmetalation-aldimine addition sequence,” Org. Biomol. Chem. 2004, 2, 443-445.
Lu, G.; Janjic, B.M.; Janjic, J.; Whiteside, T.L.; Storkus, W.J.; Vujanovic, N.L. “Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1), -beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand,” J. Immunol. 2002, 168, 1831-1839.
Selected Presentations
Janjic, J.M.; Patrick, M.J.; Schmidt, B.F.; Mailliard, R.; Waggoner, A.S.; Ahrens, E.T. “Multimodal fluorine containing nanoemulsions with biosensing properties” World Molecular Imaging Congress, Montreal, Canada 2009
Janjic, J.M.; Kadayakkara, D.K.K.; Pusateri, L.K.; Ahrens, E.T. “Novel perfluorocarbon nanoemulsions for 19F MRI cell trackgin of two cell populations in vivo” International Society for Magnetic Resonance in Medicine International Meeting, Toronto, Hawaii, 2009
Janjic, J.M.; Kadayakkara, D.K.K.; Hitchens, K.T.; Ahrens, E.T. “ Multispectral 19F MRI Reagents – Design, Synthesis and Biological Evaluation” American Chemical Society National Meeting, Philadelphia, PA, 2008, invited oral presentation
Janjic, J.M.; Srinivas, M.; Kadayakkara, D.K.K.; Ahrens, E.T. “Synthesis of novel dual-mode ’self-delivering’ nanoparticles for in vivo fluorine-19 MRI and fluorescence cell tracking” Joint Molecular Imaging Conference, Providence, RI, 2007, oral presentation
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