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David
A. Johnson, Ph.D.
Associate Professor of
Pharmacology
Director of Graduate Studies
408A Mellon Hall
T 412.396.5952
E johnsond@duq.edu |
| Educational Background |
B.A. (Biology)--Hofstra University;
M.S., Ph.D. (Pharmacology)-- Massachusetts College
of Pharmacy and Allied Health Sciences Post Doctoral
Fellow,
Harvard School of Public Health
Senior Post Doctoral Fellow, Interneuron Pharmaceuticals,
Inc.
Courses Taught
- Biological Sciences Core Pharmacology--Drug
- Mechanisms
I and II Methods of Evaluation of Drug
- Action and
Toxicity Drug Mechanisms Pathophysiology
Scientific/Professional Affiliations
- American Association of Colleges of Pharmacy
- American Society of Pharmacology and Experimental
- Therapeutics Pittsburgh Neuroscience Society Society
for Neuroscience Research Interests Pharmacology
of Memory
Research Interests
- Pharmacology of Memory
- Vascular Pharmacology
- Biology of Aging
- Eating Disorders
Grant Awards
- As Co-investigator on the RO-1grant “Cholinergic
esions and Age Related Cognitive Impairment”
funded by the National Institute on Aging, awarded
a subcontract from the University of Pittsburgh
for $292,466 over 5 years.
- National Institutes of
Health (National Institute of Aging; RO-1): DHEAS
Sulfatase inhibition and Cognition in Lesioned Rats.
$411,000 Funded for Academic Years (2000-2004).
- Faculty Development Award:
The Effect of Neurosteroids on Memory in Cognitively
Impaired Rats. $5,000 Funded for Academic Year (1998-1999)
- Hunkele Foundation for
Dread Disease Award: The Effect of Steroid Sulfatase
Analogs on GABA Receptor Binding and Memory. $6,000
Funded for Academic Year (1997-98)
Select Publications
- Maher, T.J. and Johnson, D.A.: Receptors and drug action. In: Principles of Medicinal Chemistry, 6th ed., Foye, Lemke and Williams Eds., Lippincott Williams & Wilkins, Baltimore, MD, 2007.
- Rutkowski, J.L., Fennell, J.W., Kern II, J.C., Madison, D., Johnson, D.A.: Inhibition of alveolar osteitis in mandibular tooth extraction sites using platelet rich plasma (PRP). Journal of Oral Implantology, 33 (3): 116-121, 2007.
- Gibbs, R.B., Johnson, D.A.: Cholinergic lesions produce task-selective effects related to response pattern and strategy. Neurobiology of Learning and Memory, 88 (1): 19-32, 2007
- Rutkowski, J.L. and Johnson, D.A.: Clinical concerns of alendronate use. Journal of Oral & Maxillofacial Surgery, 65(2): 363-4, 2007.
- Fitz, N., Gibbs, R.B., Johnson, D.A.: Aversive stimuli masks impairment of acquisition of delayed matching to position T-maze task resulting from selective lesion of septo-hippocampal cholinergic projections. Brain Res. Bull. 69: 660-665, 2006.
- Johnson, D.A.: Pharmacology. In Appleton & Lange's Review for the USMLE Step 3, 4th ed., D. Briscoe, Editor, McGraw-Hill, NY. 2005.
- Pokala, V.N., Li, P.-K., Johnson, D.A.: Steroid sulfatase inhibition: effects on learning and memory. Current Topics in Steroid Research. 4: 265-269, 2004.
- Gibbs, R.B., Gabor, R., Cox, T., Johnson, D.A.: Raloxifene enhances cholinergic function, but not learning, in ovariectomized rats. Psychoneuroendocrinology 29: 741-748, 2004.
- Gabor, R., Nagle, R., Johnson, D.A., Gibbs, R.B.: Estrogen enhances potassium-stimulated acetylcholine release in the rat hippocampus. Brain Res. 962: 244-247, 2003.
- Johnson, D.A. and Li, P.-K.: Sulfatase, Steroid. In: Wiley Encyclopedia of Molecular Medicine, T.E. Creighton Ed. New York, NY, John Wiley & Sons, online: http://www.mrw.interscience.wiley.com/embm/ January 2002.
- Johnson, D.A., Zambon, N.J., and Gibbs, R.B.: Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning of a delayed matching to position T-maze paradigm. Brain Res.,943: 132-141, 2002.
- Dr. David A. Johnson, "Receptors and Drug Action,"
with Dr. Timothy J. Maher, Foye's Principles of
Medicinal Chemistry, 5th edition, David A. Willams
and Thomas L. Lemke eds.; Lippincott Williams &
Wilkins, Baltimore, Md., 2002.
- Johnson, D.A., Wu, T.-H.,
Li, P.-K., Maher, T.J.: The Effect of Steroid Sulfatase
Inhibition on Learning and Spatial Memory. Brain
Res., 865:286-290, 2000.
- Maher, T.J. and Johnson,
D.A.: Receptors and drug action. In: Principles
of Medicinal Chemistry, 5th ed., Foye, Lemke and
Williams Eds. Baltimore, MD, Williams & Wilkins.
In press, 2000.
- Flood, J.F., Farr, S.A.,
Johnson, D.A., Li, P.-K., Morley, J.E.: Peripheral
steroid sulfatase inhibition potentiates improvement
of memory retention for hippocampally administered
dehydroepiandrosterone sulfate but not pregnenolone
sulfate. Psychoneuroendocrinology, 24: 799-811,
1999.
- Myers, J.P., Johnson, D.A.,
and McVey, D.E.: Caffeine in the modulation of brain
function. In: Caffeine and Behavior: Current Views
and Research Trends. B. S. Gupta and U. Gupta eds.,
CRC Press, Boca Raton, pp. 17-30, 1999.
- Johnson, D.A., Li, P.-K.,
and Rhodes, M.E.: Enhancement of excitatory neurosteroids
via inhibition of steroid sulfatase. Emerging Therapeutic
Targets, 2 (2): 245-247, 1998.
- Gibbs, R.B., Burke, A.M,
and Johnson, D.A.: Estrogen replacement attenuates
effects of scopolamine and lorazepam on memory acquisition
and retention. Hormones and Behavior, 34: 112-125,
1998.
- Chu, G.-H., Milano, S.,
Kluth, L., Rhodes, M.E., Boni, R., Johnson, D.A.,
and Li, P.-K.: 'Structure-activity-relationship
studies of the amide functionality in (p-O-sulfamoyl-N)-alkanoyl
tyramines as estrone sulfatase inhibitors."
Steroids, 1997, 62: 530-537.
- Rhodes, M.E., Li, P.-K.,
Burke, A.M., and Johnson, D.A.:"Enhanced Plasma
DHEAS, Brain Acetylcholine and Memory Mediated by
Steroid Sulfatase Inhibition," Brain Research,
1997, 773:28-32.
- Johnson, D.A., Li, P.-K.,
Boni, R.L. and Rhodes, M.E., "Chronic Steroid
Sulfatase Inhibition by (p-O-Sulfamoyl)-N-Tetradecanoyl
Tyramine Increases Dehydroepiandrosterone Sulfate
in Whole Brain," Life Sciences, 1997, Vol.
61, No. 24, 355-359.
- Johnson, D.A.: "Pharmacology."
In Appleton and Lange's Review for the USMLE Step
3, 2nd ed. S.L. Jacobs, Editor, pp. 53-65. Norwalk,
CT: Appleton & Lange, 1997.
- Gibbs, R.B., Hashhash,
A., and Johnson, D.A.: "Effects of estrogen
on potassium-evoked release in the hippocampus and
overlying cortex of adult rats." Brain Res.,
1997, 749: 143-146.
- Johnson, D.A. and O'Toole,
S., "Psychobiology and Psychopharmacotherapy
of Unipolar Major Depression: A Review." Archives
of Psychiatric Nursing, 1997, Vol. XI, No.6, 304-313.
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