Wilson S. Meng, Ph.D.
Associate Professor of Pharmaceutical
Sciences

413 Mellon Hall
T 412.396.6366
F 412.396.4660
E meng@duq.edu
H http://www.home.duq.edu/~meng/

B.S. (Pharmacy), University of Maryland at Baltimore
Ph.D. (Pharmaceutical Sciences), University of Southern California
Postdoctoral Research Fellow, University of California, Los Angeles

• T-Cell Epitope Prediction and Structure-Based Vaccine Design
• Non-Viral Gene Delivery and Genetic Immunization
• Pharmacodynamics of Dendritic Cells

• NIH NCI R15 (AREA) - "Rational Design of Peptide-Based Tumor Vaccines". PI: WS Meng. 03/04-02/07, Total cost awarded $192,005.

Honors and Awards

• 2005-2006 Apple Polishing Award for Excellence in Faculty Performance,Duquesne University
• 2004 Excellence in Teaching Award, Division of Pharmaceutical Sciences, Duquesne University
• 2003 Young Investigator Award, Division of Pharmaceutical Sciences, Duquesne University
• Jonsson Cancer Foundation Post-doctoral Fellowship (1999-2000)
• American Foundation for Pharmaceutical Education (AFPE) Pre-doctoral Fellowship (1996-1998)
• Charles and Charlotte Krown Fellowship (1996-1997)
• Conrad Medicinal Chemistry Award (1991)
• Grace Foundation Fellowship (1989-1991)
• National Dean's List (1988-1989)
• CRC Press Freshman Chemistry Award (1987)
• Rho Chi Pharmacy Honor Society (inducted in 1990, Maryland chapter)

• Jia, L, Kovacs, J.R., Zheng, Y., Shen, H., Gawalt, E.S. and Meng, W.S* 2008. "Expansion of Foxp3-expressing Regulatory T Cells in vitro from Dendritic Cells Engineered with Polymeric Particles Carrying Plasmid Encoding Interleukin-10." Biomaterials, 29(9):1250-61.
• Zheng, Y., Kovacs, J.R., Gawalt, E.S., Shen, H., and Meng, W.S.* 2006. “Characterization of Particles Fabricated with Poly (D, L-lactic-co-glycolic acid) and an Ornithine-Histidine Peptide as Carriers of Oligodeoxynucleotide for Delivery into Primary Dendritic Cells” Journal of Biomaterials Science,
  Polymer Edition, 17(12): 1389-1403.
• Joseph, M.A., Mitchell, L.M., Evanseck, J.D., Kovacs, J.R., Jia, L., Shen, H., and Meng, W.S.* 2007 “Secondary Anchor Substitutions in a HLA-A*0201-Restricted T Cell Epitope Derived from Her-2/neu” Molecular Immunology, 44(4):322-31.
• Jia, L., Kovacs, J.R., Zheng, Y., Gawalt, E.S., Shen, H., and Meng, W.S.* 2006. "Attenuated Alloreactivity of Dendritic Cells Engineered with Surface-Modified Microspheres Carrying a Plasmid Encoding Interleukin-10." Biomaterials, 27(9):2076-2082.
• Meng, W.S.*and Butterfield, L.H. 2005. "Activation of Antigen-Presenting Cells by DNA Delivery Vectors." (Review) Expert Opinion on Biological Therapy, 5(8), 1019-1028.
• Kovacs, J.R., Zheng, Y., Shen, H., and Meng, W.S*. 2005. "Polymeric Microspheres as Stabilizing Anchors for Oligonucleotide Delivery to Dendritic Cells." Biomaterials, 26(33), 6754-61.
• Liao, Y-P., Wang, C-C., Butterfield, L.H., Economou, J.S., Ribas, A., Meng, W.S., Iwamoto, K.S., and McBride, W.H. 2004. Ionizing Radiation Affects Human MART-1 Melanoma Antigen Processing and Presentation by Dendritic Cells. Journal of Immunology (173), 2462-2469.
• Chamarthy, S.P., Jia, L., Kovacs, J.R., Anderson, K.R., Shen, H., Firestine, S.M., and Meng, W.S*. 2004. Gene Delivery to Dendritic Cells Facilitated by a Tumor Necrosis Factor Alpha-Competing Peptide. Molecular Immunology, 41 (8), 741-749.
• Butterfield, L.H., Ribas, A. Meng, W.S., Dissette, V.B., Amarnani, S. Vu, H.T., Seja, E., Todd, K., Glaspy, J.A., McBride W.H. and Economou, J.S. 2003. T Cell Responses To HLA-A*0201 Immunodominant Peptides Derived From Alpha Fetoprotein in Patients with Hepatocellular Cancer. Clinical Cancer Research, 9(16), 5902-5908.
• Chamarthy, S.P., Kovacs, J.R., Gattens, D., McClelland, E., and Meng, W.S*. 2003. A Cationic Peptide Consists of Ornithine and Histidine Repeats Augments Gene Transfer in Dendritic Cells. Molecular Immunology, 40 (8), 479-486.
• Meng, W.S. and Butterfield, L.H. 2002. Rational Design of Peptide-Based Tumor Vaccine (Review). Pharmaceutical Research. 19 (7): 926-932.
• Meng, W.S., Butterfield, L.H., Ribas, A., Dissette, V., Heller, J.B., Miranda, G.A., Glaspy, J.A., McBride, W.H. and Economou, J.S. 2001. Alpha Fetoprotein-Specific Tumor Immunity Induced by Plasmid Prime-Adenovirus Boost Genetic Vaccination. Cancer Research, 61 (24): 8782.
• Ribas, A., Butterfield, L.H., Amarnani, S., Dissette, V.B., Kim, D., Meng, W.S., Miranda, G.A., Wang, H-J., McBride, W.H., Glaspy, J.A., and Economou, J.S. 2001. CD40L Crosslinking Bypasses the Absolute Requirement for CD4 Cells During Immunization with Melanoma Antigen Gene-Modified Dendritic Cells. Cancer Research. 61 (24):8787.
• Meng, W.S., Butterfield, L.H., Ribas, A., Heller, J.B., Dissette, V., Glaspy, J.A., McBride, W.H. and Economou, J.S. 2001. Fine specificity analysis of an HLA-A*0201-restricted immunodominant peptide derived from human alpha-fetoprotein. Molecular Immunology, 2001. vol. 37, 943-950.
• Butterfield, L.H., Meng, W.S., Koh, A., Vollmer, C.M., Ribas, A., Dissette, V., Lee, E., Faull, K., Glaspy, J.A., McBride, W.H. and Economou, J.S. 2001. Generation of human T-cell responses to strong binding HLA-A2.1-restricted peptide epitopes derived from alpha-fetoprotein. Journal of Immunology, vol. 166, 5300-5309.
• Meng, W.S., von Grafenstein, H., and Haworth, I.S. 2000. Water Dynamics at the interface of four different MHC-peptide complexes. International Immunology, vol. 12, no. 7, 949-957.
• Meng, W.S., Bui, H-H., and Haworth, I.S. 2000. Exploiting the Peptide-MHC Water Interface in the Computer-Aided Design of Non-Natural Peptides that Bind to the Class I MHC Molecule HLA-A2. Molecular Simulation, vol. 24, 215-228.
• Ribas, A., Butterfield, L.H., Hu, B, Dissette, V.B., Meng, W.S., Koh, A., Andrews, K.J., Lee, M., Amar, S.N., Glaspy, J.A., McBride, W.H., and Economou, J.S. 2000. Immune deviation and Fas-mediated deletion limit antitumor activity after multiple dendritic cell vaccinations in mice. Cancer Research, vol. 60, n.8: 2218-2224.
• Gurlo, T., Meng, W.S., Bui, H-H., Haworth, I.S. and von Grafenstein, H. 1999. Experimental Evidence for the Presence of a Water Network at the Peptide-MHC Interface. Immunology Letters, vol. 70:139-41.
• Butterfield, L.H., Koh, A., Meng, W., Vollmer, C.M., Ribas, A., Dissette, V., Lee, E., Glaspy, J.A., McBride, W.H. and Economou, J.S. 1999. Generation of human T-cell responses to an HLA-A2.1-restricted peptide epitope derived from alpha-Fetoprotein. Cancer Research, vol.59, n.13: 3134-3142.
• Meng, W.S., Bhavaraju, A.V., Haworth, I.S. and von Grafenstein, H. Modeling of the Non-Obese Diabetic Mouse Class II MHC Molecule I-Ag7. 1998. Protein and Peptide Letters, vol. 5, No. 2, 75-82.
• Meng W.S., von Grafenstein, H. and Haworth, I.S. 1997. A Model of Water Structure Inside the HLA-A2 Peptide Binding Groove. International Immunology, vol 9, No. 9, 1339-1346.
• Meng W.S., Gallaher, T.K., von Grafenstein, H. and Haworth, I.S. 1996. Sequence Dependent Conformational Motion of a Peptide Bound to a Class I MHC Molecule. Protein and Peptide Letters, vol. 3, No. 1, 51-58.